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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A 72-year-old woman with a long history of schizophrenia has been admitted to the state hospital because of a recent relapse while on risperidone 5 mg daily. It is decided to use an equivalent dose of ziprasidone. Which reference would most likely provide this information?

A) Diagnostic and Statistical Manual of Mental Disorders - V
B) Drug Facts & Comparisons
C) The Sanford Guide
D) Martindale: The Complete Drug Reference

2. Initial efficacy data on an experimental drug in the United States are usually collected in:

A) Phase III trials.
B) Phase trials.
C) Phase trials.
D) Phase IV trials.

3. A clinical trial is being designed to evaluate the efficacy of an intermediate-acting niacin preparation in a population with regard to amelioration of coronary artery disease risk.
Bioethical considerations would restrict recruitment of subjects with poorly controlled diabetes mellitus, recent gastroduodenal ulcer disease, or hyperuricemia. Which principle would consider these patients to be ineligible for enrollment?

A) Equipoise
B) Justice
C) Autonomy
D) Beneficence

4. A 58-year-old man presents complaining of unsteady gait. Past medical history is significant for diabetes mellitus, gastroparesis, and depression. The patient exhibits a slight shuffling gait, mild limb rigidity, and decreased speed in performing rapid alternating movement. Current daily medications are bupropion, glyburide, metoclopramide, and omeprazole. Which of the following would be the most appropriate initial management for the presenting complaint?

A) Discontinue metoclopramide.
B) Begin ropinirole.
C) Begin carbidopa/levodopa.
D) Discontinue bupropion.

5. The Randomized Aldactone Evaluation Study (RALES) yielded the following results:
* Placebo death rate: 386/841
* Spironolactone death rate: 284/822
Given these data, which of the following is the relative risk reduction for death with spironolactone, in comparison with placebo?

A) 24%
B) 11%
C) 31%
D) 45%

Solutions: